Virulence profiles of wild-type, P.1 and delta SARS-CoV-2 variants in K18-hACE2 transgenic mice
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Diretoria Técnica | pt_BR |
dc.contributor | Centro Bioindustrial | pt_BR |
dc.contributor.author | Santos, Yasmin da Silva | pt_BR |
dc.contributor.author | Gamon, Thais Helena Martins | pt_BR |
dc.contributor.author | de Azevedo, Marcela Santiago Pacheco | pt_BR |
dc.contributor.author | Covas, Dimas Tadeu | pt_BR |
dc.contributor.author | Curi, Rui | pt_BR |
dc.date.accessioned | 2023-05-04T14:26:51Z | - |
dc.date.available | 2023-05-04T14:26:51Z | - |
dc.date.issued | 2023 | pt_BR |
dc.identifier.citation | Santos YS, Gamon THM, de Azevedo MSP, Covas DT, Curi R. Virulence profiles of wild-type, P.1 and delta SARS-CoV-2 variants in K18-hACE2 transgenic mice. Viruses. 2023 Apr; 15(4):999. doi:10.3390/v15040999. | pt_BR |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/4889 | - |
dc.description.abstract | Since December 2019, the world has been experiencing the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and we now face the emergence of several variants. We aimed to assess the differences between the wild-type (Wt) (Wuhan) strain and the P.1 (Gamma) and Delta variants using infected K18-hACE2 mice. The clinical manifestations, behavior, virus load, pulmonary capacity, and histopathological alterations were analyzed. The P.1-infected mice showed weight loss and more severe clinical manifestations of COVID-19 than the Wt and Delta-infected mice. The respiratory capacity was reduced in the P.1-infected mice compared to the other groups. Pulmonary histological findings demonstrated that a more aggressive disease was generated by the P.1 and Delta variants compared to the Wt strain of the virus. The quantification of the SARS-CoV-2 viral copies varied greatly among the infected mice although it was higher in P.1-infected mice on the day of death. Our data revealed that K18-hACE2 mice infected with the P.1 variant develop a more severe infectious disease than those infected with the other variants, despite the significant heterogeneity among the mice. | pt_BR |
dc.description.sponsorship | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo | pt_BR |
dc.description.sponsorship | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | pt_BR |
dc.description.sponsorship | (FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro | pt_BR |
dc.description.sponsorship | (FIOCRUZ) Fundação Oswaldo Cruz | pt_BR |
dc.format.extent | 999 | pt_BR |
dc.language.iso | English | pt_BR |
dc.relation.ispartof | Viruses | pt_BR |
dc.rights | Open access | pt_BR |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_BR |
dc.title | Virulence profiles of wild-type, P.1 and delta SARS-CoV-2 variants in K18-hACE2 transgenic mice | pt_BR |
dc.type | Article | pt_BR |
dc.rights.license | CC BY | pt_BR |
dc.identifier.doi | 10.3390/v15040999 | pt_BR |
dc.contributor.external | (USP) Universidade de São Paulo | pt_BR |
dc.contributor.external | (FIOCRUZ) Fundação Oswaldo Cruz | pt_BR |
dc.contributor.external | Hospital Israelita Albert Einstein | pt_BR |
dc.contributor.external | Macquarie University | pt_BR |
dc.contributor.external | (UNESP) Universidade Estadual Paulista Júlio de Mesquita Filho | pt_BR |
dc.contributor.external | (UNICSUL) Universidade Cruzeiro do Sul | pt_BR |
dc.identifier.citationvolume | 15 | pt_BR |
dc.identifier.citationissue | 4 | pt_BR |
dc.subject.keyword | SARS-CoV-2 | pt_BR |
dc.subject.keyword | COVID-19 | pt_BR |
dc.subject.keyword | gamma variant | pt_BR |
dc.subject.keyword | delta variant | pt_BR |
dc.subject.keyword | variants of concern | pt_BR |
dc.subject.keyword | K18-hACE2 | pt_BR |
dc.relation.ispartofabbreviated | Viruses | pt_BR |
dc.identifier.citationabnt | v. 15, n. 4, 999, abr. 2023 | pt_BR |
dc.identifier.citationvancouver | 2023 Apr; 15(4):999 | pt_BR |
dc.contributor.butantan | Covas, Dimas Tadeu|:Outros|:Diretoria Técnica|: | pt_BR |
dc.contributor.butantan | Curi, Rui|:Outros|:Centro Bioindustrial|: | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/06747-4 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/06409-1 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/03163-1 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2015/26722-8 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/12068-5 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/12277-0 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/04923-0 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/18257-1 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/15549-1 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/04923-0 | pt_BR |
dc.sponsorship.butantan | (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/10127-1 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦302917/2019-5 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦408636/2018-1 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦304033/2021-9 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦301524/2019-0 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦307854/2018-3 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦409216/2018-6 | pt_BR |
dc.sponsorship.butantan | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦316462/2021-7 | pt_BR |
dc.sponsorship.butantan | (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88887.509097/2020-00 | pt_BR |
dc.sponsorship.butantan | (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦18/15549-1 | pt_BR |
dc.sponsorship.butantan | (FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro¦¦E-26/200.314/2022-260923 | pt_BR |
dc.sponsorship.butantan | (FIOCRUZ) Fundação Oswaldo Cruz¦¦VPPCB-005-FIO-20-2-49 | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
dc.description.dbindexed | Yes | pt_BR |
item.fulltext | Com Texto completo | - |
item.openairetype | Article | - |
item.languageiso639-1 | English | - |
item.grantfulltext | open | - |
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