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Time-dependent vaccine efficacy estimation quantified by a mathematical model

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dc.contributorDiretoria Técnicapt_BR
dc.contributor.authorLoria, Jenniferpt_BR
dc.contributor.authorAlbani, Vinicius V. L.pt_BR
dc.contributor.authorCoutinho, Francisco A. B.pt_BR
dc.contributor.authorCovas, Dimas Tadeupt_BR
dc.contributor.authorStruchine, Claudio J.pt_BR
dc.contributor.authorZubelli, Jorge P.pt_BR
dc.contributor.authorMassad, Eduardopt_BR
dc.date.accessioned2023-05-16T11:32:28Z-
dc.date.available2023-05-16T11:32:28Z-
dc.date.issued2023pt_BR
dc.identifier.citationLoria J, Albani VV.L., Coutinho FA.B., Covas DT, Struchine CJ., Zubelli JP., et al. Time-dependent vaccine efficacy estimation quantified by a mathematical model. PloS One. 2023 May; 18(5):e0285466. doi:10.1371/journal.pone.0285466.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4905-
dc.description.abstractIn this paper we calculate the variation of the estimated vaccine efficacy (VE) due to the time-dependent force of infection resulting from the difference between the moment the Clinical Trial (CT) begins and the peak in the outbreak intensity. Using a simple mathematical model we tested the hypothesis that the time difference between the moment the CT begins and the peak in the outbreak intensity determines substantially different values for VE. We exemplify the method with the case of the VE efficacy estimation for one of the vaccines against the new coronavirus SARS-CoV-2.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiropt_BR
dc.description.sponsorship(FAPESC) Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarinapt_BR
dc.description.sponsorship(UCR) Universidad de Costa Ricapt_BR
dc.format.extente0285466pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPloS Onept_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleTime-dependent vaccine efficacy estimation quantified by a mathematical modelpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1371/journal.pone.0285466pt_BR
dc.contributor.externalInstituto de Matemática Pura e Aplicadapt_BR
dc.contributor.external(UCR) Universidad de Costa Ricapt_BR
dc.contributor.external(UFSC) Universidade Federal de Santa Catarinapt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(FGV) Fundação Getulio Vargaspt_BR
dc.contributor.externalKhalifa Universitypt_BR
dc.identifier.citationvolume18pt_BR
dc.identifier.citationissue5pt_BR
dc.relation.ispartofabbreviatedPloS Onept_BR
dc.identifier.citationabntv. 18, n. 5, e0285466, mai. 2023pt_BR
dc.identifier.citationvancouver2023 May; 18(5):e0285466pt_BR
dc.contributor.butantanCovas, Dimas Tadeu|:Outros|:Diretoria Técnica|:pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦305544/2011-0pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦307873/2013-7pt_BR
dc.sponsorship.butantan(FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro¦¦E-26/202.927/201pt_BR
dc.sponsorship.butantan(FAPESC) Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina¦¦00002847/202pt_BR
dc.sponsorship.butantan(UCR) Universidad de Costa Rica¦¦OAICE-CAB-02-022-201pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.grantfulltextopen-
item.languageiso639-1English-
item.fulltextCom Texto completo-
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