Essential metabolism required for T and B lymphocyte functions: an update

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dc.contributorPrograma de Pós-Doutoradopt_BR
dc.contributorLab. Fisiopatologiapt_BR
dc.contributor(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorDiniz, Vinicius Leonardo Sousapt_BR
dc.contributor.authorAlvares-Saraiva, Anuska Marcelinopt_BR
dc.contributor.authorSerdan, Tamires Duarte Afonsopt_BR
dc.contributor.authordos Santos, Laiane Cristinapt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.identifier.citationDiniz VLS, Alvares-Saraiva AM, Serdan TDA, dos Santos LC, Curi R. Essential metabolism required for T and B lymphocyte functions: an update. Clin Sci. 2023 May; 137(10):807–821. doi:10.1042/CS20220869.pt_BR
dc.description.abstractLymphocytes act as regulatory and effector cells in inflammation and infection situations. A metabolic switch towards glycolytic metabolism predominance occurs during T lymphocyte differentiation to inflammatory phenotypes (Th1 and Th17 cells). Maturation of T regulatory cells, however, may require activation of oxidative pathways. Metabolic transitions also occur in different maturation stages and activation of B lymphocytes. Under activation, B lymphocytes undergo cell growth and proliferation, associated with increased macromolecule synthesis. The B lymphocyte response to an antigen challenge requires an increased adenosine triphosphate (ATP) supply derived mainly through glycolytic metabolism. After stimulation, B lymphocytes increase glucose uptake, but they do not accumulate glycolytic intermediates, probably due to an increase in various metabolic pathway ‘end product’ formation. Activated B lymphocytes are associated with increased utilization of pyrimidines and purines for RNA synthesis and fatty acid oxidation. The generation of plasmablasts and plasma cells from B lymphocytes is crucial for antibody production. Antibody production and secretion require increased glucose consumption since 90% of consumed glucose is needed for antibody glycosylation. This review describes critical aspects of lymphocyte metabolism and functional interplay during activation. We discuss the primary fuels for the metabolism of lymphocytes and the particularities of T and B cell metabolism, including the differentiation of lymphocytes, stages of development of B cells, and the production of antibodies.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.relation.ispartofClinical Sciencept_BR
dc.rightsRestricted accesspt_BR
dc.titleEssential metabolism required for T and B lymphocyte functions: an updatept_BR
dc.contributor.external(UNICSUL) Universidade Cruzeiro do Sulpt_BR
dc.contributor.externalCurtin Universitypt_BR
dc.contributor.external(UNIP) Universidade Paulistapt_BR
dc.contributor.external(NYU) New York Universitypt_BR
dc.contributor.externalSouthern Cross Universitypt_BR
dc.contributor.externalFEFISO (Faculdade de Educação Física da Associação Cristã de Moços de Sorocaba)pt_BR
dc.contributor.external(UFSC) Universidade Federal de Santa Catarinapt_BR
dc.subject.keywordantibody productionpt_BR
dc.subject.keywordb Cellpt_BR
dc.relation.ispartofabbreviatedClin Scipt_BR
dc.identifier.citationabntv. 137, n. 10, 807–821, mai. 2023pt_BR
dc.identifier.citationvancouver2023 May; 137(10):807–821pt_BR
dc.contributor.butantanAlvares-Saraiva, Anuska Marcelino|:Pós-Doc Egresso|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantandos Santos, Laiane Cristina|:Técnico|:(LEDM) Lab. Estratégico de Diagnóstico Molecular|:pt_BR
dc.contributor.butantanCuri, Rui|:Outros|:Centro Bioindustrial|:pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/13119-2pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/09868-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/07283-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/07818-0pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦pt_BR
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