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Human pegivirus-1 detection and genotyping in brazilian patients with fulminant hepatitis

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dc.contributor(LCC) Lab. Ciclo Celularpt_BR
dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorda Silva, Anielly Saranapt_BR
dc.contributor.authorde Campos, Gabriel Montenegropt_BR
dc.contributor.authorVillanova, Marcia Guimarãespt_BR
dc.contributor.authorElias, Maria Carolinapt_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.contributor.authorSlavov, Svetoslav Nanevpt_BR
dc.date.accessioned2023-10-05T18:01:10Z-
dc.date.available2023-10-05T18:01:10Z-
dc.date.issued2023pt_BR
dc.identifier.citationda Silva AS, de Campos GM, Villanova MG, Elias MC, Sampaio SC, Slavov SN. Human pegivirus-1 detection and genotyping in brazilian patients with fulminant hepatitis. Pathogens. 2023 Sep; 12(9):1122. doi:10.3390/pathogens12091122.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5119-
dc.description.abstractFulminant hepatitis is a severe clinical disease characterized by a marked decline in liver function and encephalopathy. In a previous survey, using metagenomics in a group of 27 patients with this clinical condition, we observed an expressive quantity of reads of the Human pegivirus-1 (HPgV-1). Therefore, the objective of this study was to evaluate the frequency, molecular features, and HPgV-1 circulating genotypes in patients with fulminant hepatitis. After testing the collected plasma samples, we discovered twelve samples (44.4%) that were positive for HPgV-1 RNA (using both real-time and nested PCR). The positive samples presented a mean cycle threshold (Ct) of 28.5 (±7.3). Genotyping assignments revealed that all HPgV-1 positive samples belonged to the HPgV-1 genotype 2 (both subgenotypes 2A and 2B were identified). Although HPgV-1 is considered a commensal virus, little is known regarding its prevalence and genotypes in cases of fulminant hepatitis. More research is needed to understand whether HPgV-1 can be implicated in clinical disorders and infectious diseases.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorshipPON Ricerca e Innovazionept_BR
dc.format.extent1122pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPathogenspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleHuman pegivirus-1 detection and genotyping in brazilian patients with fulminant hepatitispt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/pathogens12091122pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UNB) Universidade de Brasíliapt_BR
dc.contributor.external(FIOCRUZ) Fundação Oswaldo Cruzpt_BR
dc.contributor.externalUniversity of Campus Bio-Medico di Romapt_BR
dc.identifier.citationvolume12pt_BR
dc.identifier.citationissue9pt_BR
dc.subject.keywordfulminant hepatitispt_BR
dc.subject.keywordhuman pegvirus-1pt_BR
dc.subject.keywordHPgV-1pt_BR
dc.subject.keywordgenotypingpt_BR
dc.subject.keywordqPCRpt_BR
dc.relation.ispartofabbreviatedPathogenspt_BR
dc.identifier.citationabntv. 12, n. 9, 1122, set. 2023pt_BR
dc.identifier.citationvancouver2023 Sep; 12(9):1122pt_BR
dc.contributor.butantanElias, Maria Carolina|:Pesquisador|:(LCC) Lab. Ciclo Celular|:pt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantanSlavov, Svetoslav Nanev|:Pesquisador|:(LCC) Lab. Ciclo Celular|:Autor de correspondência|:pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/23205-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/15826-5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/08528-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/11944-6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2022/00910-6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2022/10278-5pt_BR
dc.sponsorship.butantanPON Ricerca e Innovazione¦¦2014–2020pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
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