Cell lipid biology in infections: an overview

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dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorPrado, Luan Gaviãopt_BR
dc.contributor.authorCamara, Niels Olsen Saraivapt_BR
dc.contributor.authorBarbosa, Angela Silvapt_BR
dc.date.accessioned2023-11-13T13:42:27Z-
dc.date.available2023-11-13T13:42:27Z-
dc.date.issued2023pt_BR
dc.identifier.citationPrado LG, Camara NOS, Barbosa AS. Cell lipid biology in infections: an overview. Front Cell Infect Microbiol. 2023 Oct; 13:1148383. doi:10.3389/fcimb.2023.1148383.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5138-
dc.description.abstractLipids are a big family of molecules with a vast number of functions in the cell membranes, within the cytoplasm, and extracellularly. Lipid droplets (LDs) are the most common storage organelles and are present in almost every tissue type in the body. They also have structural functions serving as building blocks of cellular membranes and may be precursors of other molecules such as hormones, and lipoproteins, and as messengers in signal transduction. Fatty acids (FAs), such as sterol esters and triacylglycerols, are stored in LDs and are used in β-oxidation as fuel for tricarboxylic acid cycle (TCA) and adenosine triphosphate (ATP) generation. FA uptake and entrance in the cytoplasm are mediated by membrane receptors. After a cytoplasmic round of α- and β-oxidation, FAs are guided into the mitochondrial matrix by the L-carnitine shuttle system, where they are fully metabolized, and enter the TCA cycle. Pathogen infections may lead to impaired lipid metabolism, usage of membrane phospholipids, and LD accumulation in the cytoplasm of infected cells. Otherwise, bacterial pathogens may use lipid metabolism as a carbon source, thus altering the reactions and leading to cellular and organelles malfunctioning. This review aims to describe cellular lipid metabolism and alterations that occur upon infections.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent1148383pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleCell lipid biology in infections: an overviewpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3389/fcimb.2023.1148383pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume13pt_BR
dc.subject.keywordlipidpt_BR
dc.subject.keywordlipid metabolismpt_BR
dc.subject.keywordphospholipidspt_BR
dc.subject.keywordlipid dropletspt_BR
dc.subject.keywordbacterial and viral infectionspt_BR
dc.relation.ispartofabbreviatedFront Cell Infect Microbiolpt_BR
dc.identifier.citationabntv. 13, 1148383, out. 2023pt_BR
dc.identifier.citationvancouver2023 Oct; 13:1148383pt_BR
dc.contributor.butantanBarbosa, Angela Silva|Pesquisador|:Lab. Bacteriologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/01122-9pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88887.357170/2019-00pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/01122-9pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1English-
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crisitem.author.orcid0000-0002-6458-9489-
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