Crotoxin modulates macrophage phenotypic reprogramming

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dc.contributorLab. Fisiopatologiapt_BR
dc.contributorLab. Imunopatologiapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorNeves, Camila Limapt_BR
dc.contributor.authorBarbosa, Christiano Marcello Vazpt_BR
dc.contributor.authorRanéia-Silva, Priscila Andradept_BR
dc.contributor.authorFaquim Mauro, Eliana Limapt_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.date.accessioned2023-11-14T13:42:49Z-
dc.date.available2023-11-14T13:42:49Z-
dc.date.issued2023pt_BR
dc.identifier.citationNeves CL, Barbosa CMV, Ranéia-Silva PA, Faquim Mauro EL, Sampaio SC. Crotoxin modulates macrophage phenotypic reprogramming. Toxins. 2023 Oct; 15(10):616. doi:10.3390/toxins15100616.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5141-
dc.description.abstractMacrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenotype in response to the pathogen or the microenvironment. Several studies have shown that Crotoxin (CTX), the major toxin of the Crotalus durissus terrificus snake venom, has a long-lasting antitumor effect both in experimental models and in clinical trials. In this study, we show the CTX effect on the phenotypic reprogramming of macrophages in the mesenchymal tumor microenvironment or those obtained from the peritoneal cavity of healthy animals. CTX (0.9 or 5 μg/animal subcutaneously) administered concomitantly with intraperitoneal inoculation of tumor cells (1 × 107/0.5 mL, injected intraperitoneally) of Ehrlich Ascitic Tumor (EAT) modulated the macrophages phenotype (M1), accompanied by increased NO• production by cells from ascites, and was evaluated after 13 days. On the other hand, in healthy animals, the phenotypic profile of macrophages was modulated in a dose-dependent way at 0.9 μg/animal: M1 and at 5.0 μg/animal: M2; this was accompanied by increased NO• production by peritoneal macrophages only for the dose of 0.9 μg/animal of CTX. This study shows that a single administration of CTX interferes with the phenotypic reprogramming of macrophages, as well as with the secretory state of cells from ascites, influencing events involved with mesenchymal tumor progression. These findings may favor the selection of new therapeutic targets to correct compromised immunity in different systems.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent616pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleCrotoxin modulates macrophage phenotypic reprogrammingpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/toxins15100616pt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume15pt_BR
dc.identifier.citationissue10pt_BR
dc.subject.keywordrattlesnakept_BR
dc.subject.keywordmacrophage plasticitypt_BR
dc.subject.keywordcytokinespt_BR
dc.subject.keywordtumor microenvironmentpt_BR
dc.subject.keywordimmunomodulatory effectpt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 15, n. 10, 616, out. 2023pt_BR
dc.identifier.citationvancouver2023 Oct; 15(10):616pt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador|:Docente PPGTox|:Lab. Fisiopatologia|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:Autor de correspondênciapt_BR
dc.contributor.butantanFaquim Mauro, Eliana Lima|:Pesquisador|:Lab. Imunopatologiapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/11161–6pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦001pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦301685/2017–7pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦312491-2021-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.grantfulltextopen-
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item.languageiso639-1English-
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