Genetically modified ZIKA virus as a microRNA-sensitive oncolytic virus against central nervous system tumors

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dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorGabriela Machado Novaes,pt_BR
dc.contributor.authorCaroline Limapt_BR
dc.contributor.authorCarla Longopt_BR
dc.contributor.authorHo, Paulo Leept_BR
dc.date.accessioned2024-01-22T18:08:03Z-
dc.date.available2024-01-22T18:08:03Z-
dc.date.issued2024pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5234-
dc.description.abstractHere we introduce a first-in-class microRNA-sensitive oncolytic Zika virus (ZIKV) for virotherapy application against central nervous system (CNS) tumors. The described methodology produced two synthetic modified ZIKV strains that are safe in normal cells, including neural stem cells, while preserving brain tropism and oncolytic effects in tumor cells. The microRNA-sensitive ZIKV introduces genetic modifications in two different virus sites: first, in the established 3′UTR region, and secondly, in the ZIKV protein coding sequence, demonstrating for the first time that the miRNA inhibition systems can be functional outside the UTR RNA sites. The total tumor remission in mice bearing human CNS tumors, including metastatic tumor growth, after intraventricular and systemic modified ZIKV administration, confirms the promise of this virotherapy as a novel agent against brain tumors—highly deadly diseases in urgent need of effective advanced therapies.pt_BR
dc.format.extent440-456pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMolecular Therapypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleGenetically modified ZIKA virus as a microRNA-sensitive oncolytic virus against central nervous system tumorspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1016/j.ymthe.2024.01.006pt_BR
dc.contributor.externalVyro Bio Incpt_BR
dc.contributor.externalA. C. Camargo Cancer Centerpt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalHarvard Medical Schoolpt_BR
dc.contributor.externalInstituto Pasteurpt_BR
dc.contributor.externalUniversity of Cambridgept_BR
dc.identifier.citationvolume32pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordcentral nervous system tumorspt_BR
dc.subject.keywordmiRNA-sensitive oncolytic viruspt_BR
dc.subject.keywordvirus genetic engineeringpt_BR
dc.subject.keywordZika viruspt_BR
dc.subject.keywordcancer stem cellpt_BR
dc.subject.keywordglioblastomapt_BR
dc.subject.keywordmedulloblastomapt_BR
dc.subject.keywordAT/RTpt_BR
dc.subject.keywordoncolytic therapypt_BR
dc.subject.keywordtherapypt_BR
dc.subject.keywordimmunotherapypt_BR
dc.relation.ispartofabbreviatedMol Therpt_BR
dc.identifier.citationabntv. 32, n. 2, p. 440-456, fev. 2024pt_BR
dc.identifier.citationvancouver2024 Feb; 32(2):440-456pt_BR
dc.contributor.butantanHo, Paulo Lee|:Centro Bioindustrialpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextopen-
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
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