Molecular aspects involved in the mechanisms of Bothrops jararaca venom-induced Hyperalgesia: participation of NK1 Receptor and glial cells

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dc.contributorPrograma de Pós-Doutoradopt_BR
dc.contributorLab. Fisiopatologiapt_BR
dc.contributor(LEDS) Lab. Dor e Sinalizaçãopt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributorIniciação Científicapt_BR
dc.contributor.authorBom, Ariela de Oliveira Pedropt_BR
dc.contributor.authorDias-Soares, Moniquept_BR
dc.contributor.authorCorrêa, Raíssa Cristina Darrozpt_BR
dc.contributor.authorNeves, Camila Limapt_BR
dc.contributor.authorHösch, Natália Gabrielept_BR
dc.contributor.authorGabriela Gomes de Lucenapt_BR
dc.contributor.authorOliveira, Camilla Garciapt_BR
dc.contributor.authorPagano, Rosana Limapt_BR
dc.contributor.authorChacur, Maruciapt_BR
dc.contributor.authorGiorgi, Renatapt_BR
dc.date.accessioned2024-05-08T17:31:00Z-
dc.date.available2024-05-08T17:31:00Z-
dc.date.issued2024pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5313-
dc.description.abstractAccidents caused by Bothrops jararaca (Bj) snakes result in several local and systemic manifestations, with pain being a fundamental characteristic. The inflammatory process responsible for hyperalgesia induced by Bj venom (Bjv) has been studied; however, the specific roles played by the peripheral and central nervous systems in this phenomenon remain unclear. To clarify this, we induced hyperalgesia in rats using Bjv and collected tissues from dorsal root ganglia (DRGs) and spinal cord (SC) at 2 and 4 h post-induction. Samples were labeled for Iba-1 (macrophage and microglia), GFAP (satellite cells and astrocytes), EGR1 (neurons), and NK1 receptors. Additionally, we investigated the impact of minocycline, an inhibitor of microglia, and GR82334 antagonist on Bjv-induced hyperalgesia. Our findings reveal an increase in Iba1 in DRG at 2 h and EGR1 at 4 h. In the SC, markers for microglia, astrocytes, neurons, and NK1 receptors exhibited increased expression after 2 h, with EGR1 continuing to rise at 4 h. Minocycline and GR82334 inhibited venom-induced hyperalgesia, highlighting the crucial roles of microglia and NK1 receptors in this phenomenon. Our results suggest that the hyperalgesic effects of Bjv involve the participation of microglial and astrocytic cells, in addition to the activation of NK1 receptors.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent187pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen accesspt_BR
dc.titleMolecular aspects involved in the mechanisms of Bothrops jararaca venom-induced Hyperalgesia: participation of NK1 Receptor and glial cellspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins16040187pt_BR
dc.contributor.externalHospital Sírio Libanêspt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume16pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordBothrops jararacapt_BR
dc.subject.keywordhyperalgesiapt_BR
dc.subject.keywordnervous systemspt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 16, n. 4, 187, abr. 2024pt_BR
dc.identifier.citationvancouver2024 Apr; 16(4):187pt_BR
dc.contributor.butantanBom, Ariela de Oliveira Pedro|:Aluno|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:PrimeiroAutorpt_BR
dc.contributor.butantanNeves, Camila Lima|:Técnico|:Aluno Egresso|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:Lab. Fisiopatologiapt_BR
dc.contributor.butantanHösch, Natália Gabriele|:Pós-Doc|:Programa de Pós-Doutoradopt_BR
dc.contributor.butantanGabriela Gomes de Lucena|:Aluno|:Iniciação Científicapt_BR
dc.contributor.butantanGiorgi, Renata|:Pesquisador|:Lab. Fisiopatologia|::Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2012/24621-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/02897-4pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦001pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦102788/2020pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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