Germline control of somatic Kras mutations in mouse lung tumors


Butantan affiliation
Publication type
Article
Appears in Collections:
Metrics
Abstract
Somatic KRAS mutations are common in human lung adenocarcinomas and are associated with worse prognosis. In mice, Kras is frequently mutated in both spontaneous and experimentally induced lung tumors, although the pattern of mutation varies among strains, suggesting that such mutations are not random events. We tested if the occurrence of Kras mutations is under genetic control in two mouse intercrosses. Codon 61 mutations were prevalent, but the patterns of nucleotide changes differed between the intercrosses. Whole genome analysis with SNPs in (A/J x C57BL/6)F4 mice revealed a significant linkage between a locus on chromosome 19 and 2 particular codon 61 variants (CTA and CGA). In (AIRmaxxAIRmin) F2 mice, there was a significant linkage between SNPs located on distal chromosome 6 (around 135Mbp) and the frequency of codon 61 mutation. These results reveal the presence of two loci, on chromosomes 6 and 19, that modulate Kras mutation frequency in different mouse intercrosses. These findings indicate that somatic mutation frequency and type are not simple random events, but are under genetic control.
Reference
Borrego A, Cabrera WHK, Jensen JR, Corrêa MA, Ribeiro OG, Starobinas N, et al. Germline control of somatic Kras mutations in mouse lung tumors. Mol. Carcinog.. 2018 Jun;57(6):745-51. doi:10.1002/mc.22796.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/2509
Issue Date
2018


Files in This Item:

Existing users please Login
10.1002mc.22796.pdf
Size: 692.06 kB
Format: Adobe PDF
Embargoed until January 1, 2999    Request a copy
Show full item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.