The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox)

Full metadata record
DC FieldValueLanguage
dc.contributorLab. Imunopatologiapt_BR
dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributorLaboratório de Artrópodespt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.contributor.authorContreras-Bernal, Jorge Carlospt_BR
dc.contributor.authorGimenes, Sarah Natalie Cirilopt_BR
dc.contributor.authorFreitas-de-Sousa, Luciana Aparecidapt_BR
dc.contributor.authorPortes Junior, José Antoniopt_BR
dc.contributor.authorPeixoto, Pedro da Silvapt_BR
dc.contributor.authorIwai, Leo Keipt_BR
dc.contributor.authorMoura, Valéria Mourão dept_BR
dc.contributor.authorFerreira Bisneto, Pedropt_BR
dc.contributor.authorLacerda, Marcuspt_BR
dc.contributor.authorSilva, Iran Mendonça dapt_BR
dc.contributor.authorFerreira, Luiz Carlos de Limapt_BR
dc.contributor.authorOliveira, Sâmella Silva dept_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorSachett, Jacqueline de Almeida Gonçalvespt_BR
dc.contributor.authorMonteiro, Wuelton Marcelopt_BR
dc.date.accessioned2020-07-09T21:28:02Z-
dc.date.available2020-07-09T21:28:02Z-
dc.date.issued2020pt_BR
dc.identifier.citationMoura-da-Silva AM, Contreras-Bernal JC, Gimenes SNC, Freitas-de-Sousa LA, Portes Júnior JA, Peixoto PS, et al. The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). PLoS Negl. Trop. Dis.. 2020 Jun;14(6):e0008299. doi:10.1371/journal.pntd.0008299.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3060-
dc.description.abstractSnake venoms are complex mixtures of proteins with toxic activities, with many distinct isoforms, affecting different physiological targets, comprised in a few protein families. It is currently accepted that this diversity in venom composition is an adaptive advantage for venom efficacy on a wide range of prey. However, on the other side, variability on isoforms expression has implications in the clinics of human victims of snakebites and in the efficacy of antivenoms. B. atrox snakes are responsible for most of the human accidents in Brazilian Amazon and the type and abundance of protein families on their venoms present individual variability. Thus, in this study we attempted to correlate the individual venom proteome of the snake brought to the hospital by the patient seeking for medical assistance with the clinical signs observed in the same patient. Individual variability was confirmed in venoms of the 14 snakes selected for the study. The abundance of each protein family was quite similar among the venom samples, while the isoforms composition was highly variable. Considering the protein families, the SVMP group presented the best correlation with bleeding disorders and edema. Considering individual isoforms, some isoforms of venom metalloproteinase (SVMP), C-type lectin-like toxins (CTL) and snake venom serine proteinases (SVSP) presented expression levels that with statistically significant positive correlation to signs and symptoms presented by the patients as bleeding disorders, edema, ecchymosis and blister formation. However, some unexpected data were also observed as the correlation between a CTL, CRISP or LAAO isoforms with blister formation, still to be confirmed with a larger number of samples. Although this is still a small number of patient samples, we were able to indicate that venom composition modulates clinical manifestations of snakebites, to confirm at the bedside the prominent role of SVMPs and to include new possible toxin candidates for the development of toxin inhibitors or to improve antivenom selectiveness, important actions for the next generation treatments of snakebites.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extente0008299pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPlos Neglected Tropical Diseasespt_BR
dc.rightsOpen Accesspt_BR
dc.titleThe relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox)pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1371/journal.pntd.0008299pt_BR
dc.identifier.urlhttps://doi.org/10.1371/journal.pntd.0008299pt_BR
dc.contributor.externalFundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD)¦¦Brasilpt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Oeste do Pará (UFOPA)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Amazonas (UFAM)¦¦Brasilpt_BR
dc.contributor.externalInstituto Leônidas & Maria Deane (ILMD/Fiocruz Amazônia)¦¦Brasilpt_BR
dc.contributor.externalFundação Alfredo da Matta (FUAM)¦¦Brasilpt_BR
dc.identifier.citationvolume14pt_BR
dc.identifier.citationissue6pt_BR
dc.relation.ispartofabbreviatedPLoS Negl Trop Dispt_BR
dc.identifier.citationabntv. 14, n. 6, e0008299, jun. 2020pt_BR
dc.identifier.citationvancouver2020 Jun;14(6):e0008299pt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Docente Permanente PPGTOX|:Lab. Imunopatologia|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanIwai, Leo Kei|:Pesquisador:Docente Colaborador PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanGimenes, Sarah Natalie Cirilo|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanFreitas-de-Sousa, Luciana Aparecida|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanPortes Junior, José Antonio|:Aluno|:Lab. Imunopatologia|:pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Laboratório de Artrópodes|:pt_BR
dc.contributor.butantanMonteiro, Wuelton Marcelo|:Pesquisador|:|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303958/2018-9pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301778/2017-5pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦2992/2014pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦2017/24546-3pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦18/13108-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/25749-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦18/13108-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0003-1787-6634-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0002-1571-7763-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0002-8191-559X-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0002-0848-1940-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

10.1371journal.pntd.0008299.pdf
Size: 1.42 MB
Format: Adobe PDF
View/Open
Show simple item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.