Insights into the role of tick salivary protease inhibitors during ectoparasite–host crosstalk

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dc.contributor(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.authorJmel, Mohamed Aminept_BR
dc.contributor.authorAounallah, Hajerpt_BR
dc.contributor.authorBensaoud, Chaimapt_BR
dc.contributor.authorMekki, Imenpt_BR
dc.contributor.authorChmelař, Jindřichpt_BR
dc.contributor.authorFaria, Fernandapt_BR
dc.contributor.authorM’Ghirbi, Youmnapt_BR
dc.contributor.authorKotsyfakis, Michailpt_BR
dc.identifier.citationJmel MA, Aounallah H, Bensaoud C, Mekki I, Chmelař J, Faria F, et al. Insights into the role of tick salivary protease inhibitors during ectoparasite-host crosstalk. Int J Mol Sci. 2021 Jan;22:892. doi:10.3390/ijms22020892.pt_BR
dc.description.abstractProtease inhibitors (PIs) are ubiquitous regulatory proteins present in all kingdoms. They play crucial tasks in controlling biological processes directed by proteases which, if not tightly regulated, can damage the host organism. PIs can be classified according to their targeted proteases or their mechanism of action. The functions of many PIs have now been characterized and are showing clinical relevance for the treatment of human diseases such as arthritis, hepatitis, cancer, AIDS, and cardiovascular diseases, amongst others. Other PIs have potential use in agriculture as insecticides, anti-fungal, and antibacterial agents. PIs from tick salivary glands are special due to their pharmacological properties and their high specificity, selectivity, and affinity to their target proteases at the tick–host interface. In this review, we discuss the structure and function of PIs in general and those PI superfamilies abundant in tick salivary glands to illustrate their possible practical applications. In doing so, we describe tick salivary PIs that are showing promise as drug candidates, highlighting the most promising ones tested in vivo and which are now progressing to preclinical and clinical trials.pt_BR
dc.description.sponsorship(GACR) The Czech Science Foundationpt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.relation.ispartofInternational Journal of Molecular Sciencespt_BR
dc.rightsOpen accesspt_BR
dc.titleInsights into the role of tick salivary protease inhibitors during ectoparasite–host crosstalkpt_BR
dc.rights.licenseCC BY-SApt_BR
dc.contributor.externalInstitute of Parasitology of Branišovskápt_BR
dc.contributor.externalUniversity of South Bohemia České Budějovicept_BR
dc.contributor.externalUniversité de Tunis El Manarpt_BR
dc.contributor.external(CAS) Biology Centrept_BR
dc.subject.keywordprotease inhibitorspt_BR
dc.subject.keyworddrug discoverypt_BR
dc.subject.keywordtick salivapt_BR
dc.relation.ispartofabbreviatedInt J Mol Scipt_BR
dc.identifier.citationabntv. 22, n. 892, jan. 2021pt_BR
dc.identifier.citationvancouver2021 Jan;22:892pt_BR
dc.contributor.butantanAounallah, Hajer|:Aluno|:Lab. Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanFaria, Fernanda|:Pesquisador|:Lab. Biologia Molecularpt_BR
dc.sponsorship.butantanThe Czech Science Foundation (GACR)¦¦19-382 07247Spt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦001pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação Butantanpt_BR
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