Insights into the role of tick salivary protease inhibitors during ectoparasite–host crosstalk


Publication type
Article
Access rights
Open Access
Appears in Collections:
Metrics
Abstract
Protease inhibitors (PIs) are ubiquitous regulatory proteins present in all kingdoms. They play crucial tasks in controlling biological processes directed by proteases which, if not tightly regulated, can damage the host organism. PIs can be classified according to their targeted proteases or their mechanism of action. The functions of many PIs have now been characterized and are showing clinical relevance for the treatment of human diseases such as arthritis, hepatitis, cancer, AIDS, and cardiovascular diseases, amongst others. Other PIs have potential use in agriculture as insecticides, anti-fungal, and antibacterial agents. PIs from tick salivary glands are special due to their pharmacological properties and their high specificity, selectivity, and affinity to their target proteases at the tick–host interface. In this review, we discuss the structure and function of PIs in general and those PI superfamilies abundant in tick salivary glands to illustrate their possible practical applications. In doing so, we describe tick salivary PIs that are showing promise as drug candidates, highlighting the most promising ones tested in vivo and which are now progressing to preclinical and clinical trials.
Reference
Jmel MA, Aounallah H, Bensaoud C, Mekki I, Chmelař J, Faria F, et al. Insights into the role of tick salivary protease inhibitors during ectoparasite–host crosstalk. Int J Mol Sci. 2021 Jan;22:892. doi:10.3390/ijms22020892.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/3482
Issue Date
2021


Files in This Item:

Existing users please Login
10.3390ijms22020892.pdf
Description:
Size: 1.74 MB
Format: Adobe PDF
Embargoed until January 1, 2999    Request a copy
Show full item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.