A comparative study of endogenous phospholipase A2 inhibitors in the serum of Brazilian pit vipers


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Article
Language
English
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Abstract
This work compared the presence of phospholipase A2 inhibitors (PLIs) in the serum of 19 snake species maintained at Instituto Butantan to better understand the mechanisms of venom resistance in snakes and improve the treatment of snakebite. PLI was isolated from blood of 19 snake species by one-step chromatography and identified in all samples, besides its identity was confirmed through the interaction with both phospholipase A2 and anti-γPLI. These findings highlight the diversity of snake serum PLIs and emphasize the importance of structure-function studies.
Reference
Kavazoi VK, Silva CS, Fabri C, Hatakeyama DM, Souza DC, Grego KF, et al. A comparative study of endogenous phospholipase A2 inhibitors in the serum of Brazilian pit vipers. Toxicon. 2022 Apr; 213:87-91. doi:10.1016/j.toxicon.2022.04.011.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/4314
URL
https://doi.org/10.1016/j.toxicon.2022.04.011
Journal title
Issue Date
2022


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