Análise de alterações bioquímicas de pacientes infectados pelo coronavírus SARS-CoV-2: correlação entre os parâmetros hemostáticos e metabólicos

Abstract

COVID-19 is an illness caused by the new coronavirus SARS-CoV-2, which presents a Clinical Picture that varies from asymptomatic infections to severe breathing problems. According to the World Health Organization (WHO), this disease is already present in all continents, with more than 562 million diagnosed cases and 6 million deaths up to 12/07/2022. Clinical reports and studies with COVID-19 patients have demonstrated significant changes on the levels of factor VIII, von Willebrand factor, and fibrinogen and D dimmers, especially in severe cases. Metabolic alterations, such as lipid dysfunctions, as the decrease on HDL levels feature a direct correlation with changes in hemostasis and are risk factors for the increase of the sternness of the illness. Once the risk of increasing severity and lethality of the illness are related to hemostatic changes, this present study aims to statistically analyze these alterations, in face of the advance on the severity of the disease. The biochemical alterations were

analyzed through plasma laboratorial exams from patients infected by the SARS-CoV- 2 – collected on the Hospital Municipal Universitário de Taubate - and include

metabolic markers as cholesterol/triglycerides and tests related to hemostasis. These results demonstrate several statistically significant correlations between these markers, following the evolution of the severity of COVID-19 and may contribute to a better understanding of the pathophysiology of this disease. In addition, these results may also contribute to other studies and in the development of new treatments for COVID-19.