Processo de obtenção da proteína recombinante e uso da esculptina ou proteína recombinante para preparar um medicamento ou composição farmacêutica para profilaxia e/ou tratamento de doenças tromboembólicas ou como inibidor direto e específico da trombina

Abstract

The invention falls within the fields of biochemistry, molecular biology, genetics, pharmacy and medicinal chemistry, being related to biochemical and metabolic processes. More specifically, the present invention provides a novel class of proteins that inhibit thrombin, particularly direct inhibitors of thrombin modified from sculptin, identified in the transcriptomics analysis of the salivary glands of ticks, as well as fragments and recombinant protein thereof, which can be used as anticoagulant agents and for the prophylaxis and/or treatment of thromboembolic diseases.