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A pre-vaccination immune metabolic interplay determines the protective antibody response to a dengue virus vaccine

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dc.contributorCentro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributorDiretoria Técnicapt_BR
dc.contributor.authorPelletier, Adam-Nicolaspt_BR
dc.contributor.authorSanchez, Gabriela Pachecopt_BR
dc.contributor.authorIzmirly, Abdullahpt_BR
dc.contributor.authorPrecioso, Alexander Robertopt_BR
dc.contributor.authorKallás, Esper Georgept_BR
dc.date.accessioned2024-08-01T12:04:37Z-
dc.date.available2024-08-01T12:04:37Z-
dc.date.issued2024pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/5410-
dc.description.abstractProtective immunity to dengue virus (DENV) requires antibody response to all four serotypes. Systems vaccinology identifies a multi-OMICs pre-vaccination signature and mechanisms predictive of broad antibody responses after immunization with a tetravalent live attenuated DENV vaccine candidate (Butantan-DV/TV003). Anti-inflammatory pathways, including TGF-β signaling expressed by CD68low monocytes, and the metabolites phosphatidylcholine (PC) and phosphatidylethanolamine (PE) positively correlate with broadly neutralizing antibody responses against DENV. In contrast, expression of pro-inflammatory pathways and cytokines (IFN and IL-1) in CD68hi monocytes and primary and secondary bile acids negatively correlates with broad DENV-specific antibody responses. Induction of TGF-β and IFNs is done respectively by PC/PE and bile acids in CD68low and CD68hi monocytes. The inhibition of viral sensing by PC/PE-induced TGF-β is confirmed in vitro. Our studies show that the balance between metabolites and the pro- or anti-inflammatory state of innate immune cells drives broad and protective B cell response to a live attenuated dengue vaccine.pt_BR
dc.description.sponsorship(NIAID) National Institute of Allergy and Infectious Diseasespt_BR
dc.format.extent114370pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofCell Reportspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pt_BR
dc.titleA pre-vaccination immune metabolic interplay determines the protective antibody response to a dengue virus vaccinept_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.identifier.doi10.1016/j.toxicon.2024.107835pt_BR
dc.contributor.externalRPM Bioinfo Solutionspt_BR
dc.contributor.externalCase Western Reserve University School of Medicinept_BR
dc.contributor.externalEmory University School of Medicinept_BR
dc.contributor.externalKing AbdulAziz Universitypt_BR
dc.contributor.externalFaculdade Israelita de Ciências da Saúde Albert Einsteinpt_BR
dc.contributor.externalUniversite de Montrealpt_BR
dc.contributor.external(IAL) Instituto Adolfo Lutzpt_BR
dc.contributor.external(HC/HCFMUSP) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulopt_BR
dc.contributor.external(III-INCT) Instituto Nacional de Ciências e Tecnologiapt_BR
dc.contributor.externalUniversity of Washington School of Medicinept_BR
dc.contributor.externalDrexel University College of Medicinept_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume43pt_BR
dc.identifier.citationissue7pt_BR
dc.subject.keywordimmunologypt_BR
dc.subject.keywordvaccinept_BR
dc.subject.keywordDenguept_BR
dc.subject.keywordbile acidspt_BR
dc.subject.keywordsystems biologypt_BR
dc.relation.ispartofabbreviatedCell Reppt_BR
dc.identifier.citationabntv. 43, n. 7, 114370, jul. 2024pt_BR
dc.identifier.citationvancouver2024 Jul; 43(7):114370pt_BR
dc.contributor.butantanPrecioso, Alexander Roberto|:Outros|:Centro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributor.butantanKallás, Esper George|:Outros|:Diretoria Técnica|:pt_BR
dc.sponsorship.butantan(NIAID) National Institute of Allergy and Infectious Diseases¦¦5R01AI125202-03pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.languageiso639-1English-
item.grantfulltextopen-
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